AION Labs launches new startup utilizing AI to find molecular glue therapies

Israel-based AION Labs, an AI-enabled drug discovery partnership between world pharma and tech corporations, introduced the launch of a brand new startup, TenAces.

TenAces will make the most of AI, integrating biology and machine studying algorithms, to find molecular glue therapies to reinforce focused protein degradation. 

Molecular glues are protein-binding small molecules that change two protein interactions, inflicting them to come back collectively once they usually wouldn’t. The glues can probably be used to deal with most cancers and neurodegenerative illnesses. 

Protein degradation is a part of one’s protein homeostasis or how one’s cells break down previous or damaged proteins for reuse within the physique.  

TenAces, a product of AION Labs’ fifth startup problem, will use machine studying to search out naturally occurring protein interactions that may result in focused protein degradation within the hopes of discovering and creating new molecule glue therapies. 

The corporate will combine biology into growing its machine studying algorithms, creating a number of suggestions loops with moist lab, or experimental lab, validations that may, in flip, information the algorithms growth and enhance prediction capabilities. 

“We’re growing a novel answer for focused protein degradation by enabling the identification of optimum E3 degraders and designing molecular glues for elimination of disease-causing proteins. With some 85% of goal proteins presently undruggable, we are able to probably handle a variety of illnesses,” Dr. Arnout Schepers, founder and CEO of TenAces, mentioned in a press release. 

“AION Labs has confirmed invaluable in facilitating the institution of TenAces. The help of our pharma companions has been integral in shaping the corporate, offering the important assets and steerage essential to develop and ultimately commercialize options that may facilitate more practical remedy.”


AION Labs was constructed underneath a authorities tender with the help of the Israeli authorities by way of the Israel Innovation Authority. The corporate contains pharma giants AstraZeneca, Merck, Pfizer, and Teva, alongside enterprise capital agency Israel Biotech Fund, strategic companion Amazon Net Companies, and German unbiased analysis institute Bio Med X.

Earlier this month, AION introduced a strategic partnership with Israeli early-stage enterprise capital agency Amiti Ventures. The collaboration would assist enhance AION’s proficiency in biotech innovation by increasing its experience in computational know-how domains and deep know-how. 

AION introduced its first startup in 2022, OMEC.AI, which goals to construct an AI-enabled computational platform to assist researchers assess the scientific trial readiness of a drug candidate, counsel experiments to shut any recognized gaps and determine hidden security liabilities. 

Final 12 months, the corporate launched DenovAI, a startup creating an AI-powered platform to find potential antibodies from scratch after which counsel which of them can be utilized as efficient medication.

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